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KMID : 0606920120200040413
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Biomolecules & Therapeutics
2012 Volume.20 No. 4 p.413 ~ p.417
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Anxiolytic-Like Effects of Chrysanthemum indicum Aqueous Extract in Mice: Possible Involvement of GABAA Receptors and 5-HT1A Receptors
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Hong Sa-Ik
Kwon Seung-Hwan
Kim Min-Jung
Ma Shi Xun
Kwon Je-Won
Choi Seung-Min
Choi Soo-Im
Kim Sun-Yeou
Lee Seok-Yong
Jang Choon-Gon
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Abstract
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Chrysanthemum indicum Linne is an ancient herbal medicine used to treat bone and muscle deterioration, ocular infl ammation, headache, and anxiety in Korea, China, and Japan. Furthermore, tea derived from Chrysanthemum indicum Linne has been used to treat anxiety by facilitating relaxation and curing insomnia. However, no reports exist on the anxiolytic-like effects of Chrysanthemum indicum Linne water extract (CWE) in mice. In the present study, we investigated the anxiolytic-like effects of CWE using the elevated plus-maze (EPM) test in mice. CWE, at a dose of 500 mg/kg (p.o.), signifi cantly increased the time spent in the open arms of the EPM compared to a vehicle-injected control group. Moreover, the effect of CWE (500 mg/kg) was blocked by bicuculline (a selective GABAA receptor antagonist) and WAY 100635 (a selective 5-HT1A receptor antagonist). Taken together, these fi ndings suggest that the anxiolytic-like effects of CWE might be mediated by the GABAA receptor and the 5-HT1A receptor.
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KEYWORD
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Chrysanthemum indicum Linne, Anxiolytic-like effects, Elevated plus maze, GABAA receptor, 5-HT1A receptor
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